The major difference between left-handed vs right-handed guitars is the size of the strings. The thickest string on the right-handed guitar will always be on the left side, whereas the thickest string on the left-handed guitar will be on the right side.

Because the demand for guitars that are left-handed is low, many small music stores simply don't have any in stock. Even the large stores will only have one or two for every hundred right-handed guitars. The left-handed guitar, you find, will always be more expensive than the right-handed counterpart.

Although he was forced to learn to write right-handed, Kurt Cobain was naturally left-handed. Like Billy Ray Cyrus, he struggled to find affordable left-handed guitars as an up-and-coming musician.

Jimi Hendrix is undoubtedly the most influential guitarist of all time, and he fully embraced his lefty-ness. The flipped Stratocaster stemmed from necessity but eventually became a trademark, with right-handed guitarists like Stevie Ray Vaughan emulating the upside-down trem as homage.