The major difference between left-handed vs right-handed guitars is the size of the strings. The thickest string on the right-handed guitar will always be on the left side, whereas the thickest string on the left-handed guitar will be on the right side.

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Jimi Hendrix is undoubtedly the most influential guitarist of all time, and he fully embraced his lefty-ness. The flipped Stratocaster stemmed from necessity but eventually became a trademark, with right-handed guitarists like Stevie Ray Vaughan emulating the upside-down trem as homage.

One of the most famous left-handed musicians of all time, Jimi Hendrix often utilized right-handed guitars turned upside down and restrung for left-hand playing. He's most often associated with the Fender Stratocaster, which created a unique sound when flipped due to its bridge pickup.