The major difference between left-handed vs right-handed guitars is the size of the strings. The thickest string on the right-handed guitar will always be on the left side, whereas the thickest string on the left-handed guitar will be on the right side.

Jimi Hendrix is undoubtedly the most influential guitarist of all time, and he fully embraced his lefty-ness. The flipped Stratocaster stemmed from necessity but eventually became a trademark, with right-handed guitarists like Stevie Ray Vaughan emulating the upside-down trem as homage.

The cost The left-handed guitar, you find, will always be more expensive than the right-handed counterpart. When you consider the population of left-handed people (10%) and the fact that many learn to play on a standard guitar, you begin to get a picture of what the market is like for lefties.

One of the most famous left-handed musicians of all time, Jimi Hendrix often utilized right-handed guitars turned upside down and restrung for left-hand playing. He's most often associated with the Fender Stratocaster, which created a unique sound when flipped due to its bridge pickup.